Endocrine Abstracts

Introduction/Aim: Congenital hyperinsulinism (CHI) is a cause of severe hypoglycaemia in infancy. Treatment of diazoxide unresponsive patients includes the use of somatostatin analogues (octreotide given either as four s.c. injections daily or via a pump). We aimed to evaluate the use of a long acting somatostatin analogue (Lanreotide) in children with CHI, switching them from daily oral diazoxide or s.c. Octreotide injections to 4 weekly Lanreotide injections.<p class="ab...

Introduction: Polycystic ovary syndrome (PCOS) has a prevalence of 10–15% and is associated with metabolic and mental health consequences. There is evidence that structured education programmes improve illness perception, quality of life and the metabolic profile in other chronic conditions however evidence for structured patient education in PCOS is lacking.We aimed to use an iterative cycle of research to develop a pragmatic educational interventi...

Methodology: Polycystic ovary syndrome (PCOS) has a variety of signs and symptoms compromising different phenotypic presentations. Insulin resistance is a known association of PCOS. Despite the documented effect of ethnicity on insulin resistance, there is little known about the effect of ethnicity on the clinical presentations of PCOS. We compared the clinical presentations of white and South Asian (SA) women with PCOS.Methodology: Retrospective analysi...

Since 1994, after initial outpatient review (OPD) for thyrotoxicosis, we have minimised OPD attendance and provided shared-care advice to primary care physicians on thyroid function tests (TFT) and anti-thyroid drug (ATD) and levothyroxine (T4) dose titration using our electronic patient record (EPR). Using EPR data we analysed treatment (Rx) choice, effectiveness and outcomes, classifying patients as autoimmune (+ve TPO or other Graves’ features), nodular, mix...

Introduction: Women with PCOS share the underlying pathology of insulin resistance with diabetes, metabolic syndrome and have increased prevalence of obesity. Despite these well established risk factors data on long term cardiovascular outcomes are limited and conflicting.Methodology: Retrospective analysis of a multi-ethnic database of all women with PCOS attending one UK endocrine unit between 1988 and 2009. Cardiovascular (CV) events were identified b...

A 40-year-old woman, who had developed oligomenorrhoea after discontinuing the contraceptive pill at age 30, presented with a 6-month history of intermittent vomiting associated with abdominal discomfort and distension. Ultrasound, followed by laparotomy, revealed multiple bilateral ovarian luteal cysts consistent with hyperoestrogenism and ovarian-hyperfunctioning.Only 9 months post-operatively her bilateral theca ovarian cysts had recurred. Over 4 mont...

Introduction: Polycystic ovary syndrome (PCOS) is the most common endocrine abnormality in women with an estimated prevalence of 6–8%. Women with PCOS have a known increased prevalence of prediabetes (30–40%), type 2 diabetes (T2DM 10%), and metabolic syndrome (40%). We determined the prevalence of recorded PCOS through a structured primary care based T2DM screening programme.Methodology: Eligibility criterion for a structured and systematic sc...

Background: Metformin is an established treatment of polycystic ovarian syndrome (PCOS) but patient-reported outcomes with respect to its effects and tolerability have not been widely reported. About 68 patients with PCOS treated with metformin in our clinic were surveyed by questionnaire.Results: a. Demographics: 42/68 patients were currently, and 26 previously treated with metformin for PCOS. Median age and BMI was 31 years (range 16–49), and ...

Objective: To assess the effect of antithyroid drug pretreatment on radioiodine (I-131) treatment outcomes for benign thyroid disease.Method: Retrospective analysis of all patient records on the clinical database that underwent I-131 treatment for benign thyroid disease between 1989 and 2007.Results: About 544 patients were identified, 98 males (18%) and 446 females (82%). The mean age was 54 years (11-88). 464 patients (85.3%) we...

The differential diagnosis of post-partum thyrotoxicosis includes Graves' disease and post-partum thyroiditis(PPT). We present two cases which demonstrate the difficulty of interpreting 99mTc-pertechnetate scans in this setting. Case 1 is a 37 year-old lady who presented 5 months post-partum with a month history of palpitations, sweating and heat intolerance. Investigations revealed TSH < 0.01 mU/L, fT3 8.9 pmol/L (NR 10.5-22.7 pmol/L) and fT4 23.4 pmol/L (NR 3.5-6.5 pmol/)...